Clinicopathological findings of large, well-differentiated hepatocellular carcinoma.

• HAMANO Mie

  Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University

• TAKASAKI Ken

  Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University

• YAMAMOTO Masakazu

  Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University

• SAITO Akiko

  Department of medicine, Institute of Gastroenterology, Tokyo Women's Medical University

• NAKANO Masayuki

  Division of Pathlogy, Mito National Hospital

Bibliographic Information

Other Title

• 大型の高分化型肝細胞癌切除症例の臨床病理学的検討

Abstract

Seventy-one patients with well-differentiated hepatocellular carcinoma (HCC) underwent hepatectomy at our institution.<BR>Clinicopathological findings were compared between patients with large tumors (maximum diameter>3cm, n=12) and patients with small tumors (maximum diameter≤3cm, n=59). Tumor size was not correlated with age, gender, or incidence of hepatitis. Large HCCs were associated with significantly fewer complications of cirrhosis (P=0.0329) than were small HCCs. The incidence of low concentrations (≤20ng/ml) of alfa-fetoprotein (P=0.0254) and of hypervascularity on angiography (P<0.0001) were both higher in patients with large HCCs. Patients with HCCs 5cm or larger had a significantly lower incidence of multicentric lesions (P=0.0346) and of intrahepatic recurrence after surgery (P=0.0439). Histopathological examination revealed encapsulation in all large HCCs, and the portal tracts within the tumors tended to be diminished. Six of the 12 large HCCs (50%) included moderately differentiated HCC, and histological grade was not uniform in large HCCs. Large, well-differentiated HCC is distinct from small, well-differentiated HCC.

Journal

• Kanzo

  Kanzo 41 (10), 711-715, 2000

  The Japan Society of Hepatology

Keywords

• 高分化型肝細胞癌
• 大型肝細胞癌

Details

• CRID: 1390001204790387840
• NII Article ID: 10005569550
• NII Book ID: AN00047770
• DOI: 10.2957/kanzo.41.711
• ISSN: 18813593
• ISSN: 04514203
• ISSN: http://id.crossref.org/issn/04514203
• Web Site: http://www.jstage.jst.go.jp/article/kanzo1960/41/10/41_10_711/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2001098733
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed