Desensitization Therapy for Allergic Reactions of Antituberculous Drugs. Evaluation of Desensitization Therapy According to the Guideline of the Japanese Society for Tuberculosis.

DOI PubMed 2 Citations 8 References
  • KOBASHI Yoshihiro
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, Kawasaki Hospital
  • OKIMOTO Niro
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, Kawasaki Hospital
  • MATSUSHIMA Toshiharu
    Division of Respiratory Diseases, Department of Medicine, Kawasaki
  • ABE Takahiro
    Division of Respiratory Diseases, Department of Medicine, National Ehime Hospital
  • NISHIMURA Kazutaka
    Division of Respiratory Diseases, Department of Medicine, National Ehime Hospital
  • SHISHIDO Shinji
    Division of Respiratory Diseases, Department of Medicine, Kawasaki
  • KAWAHARA Shin
    Department of Respiratory Diseases, National Matsue Hospital
  • SHIGETO Eriko
    Department of Medicine, National Minami Okayama Hospital, 6Department of Respiratory Diseases, National Hiroshima Hospital
  • TAKEYAMA Hiroyasu
    Department of Medicine, National Sanyo Hospital
  • KURAOKA Toshihiko
    Department of Medicine, Yoshijima Hospital

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Other Title
  • 抗結核薬に対する減感作療法について　　ガイドラインに沿った治療成績
  • Evaluation of Desensitization Therapy According to the Guideline of the Japanese Society for Tuberculosis
  • ガイドラインに沿った治療成績

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Abstract

We prospectively evaluated the effectiveness of desensitization therapy for cases showing side-effects to antituberculous drugs (Isoniazid and Rifampicin) according to the guideline proposed by the Treatment Committee of the Japanese Society for Tuberculosis. Nineteen patients (23-88 years old, male 9, female 10) who had experienced adverse effects after receiving antituberculous drugs and underwent desensitization therapy between August 1998 and March 2000 were studied. Underlying diseases were 14 cases of pulmonary tubercu losis, 2 cases of cervical tuberculous lymphadenitis, 1 case of pulmonary atypical myco bacteriosis, 1 case of pulmonary tuberculosis and tuberculous pleuritis, 1 case of pulmo nary tuberculosis and tuberculous lymphadenitis. The regimens of treatment for tubercu losis were INH+RFP+EB in 8 cases, INH+RFP+EB+PZA in 7 cases, INH+RFP+SM in 2 cases, INH+RFP-FSM+PZA in 1 case, and INH-FRFP in 1 case. Adverse reactions were 8 cases of eruption, 7 cases of drug fever, 3 cases of drug fever and eruption, and 1 case of drug fever and cervical lymphadenopathy. The causative drugs suggested from DLST or the clinical course were RFP in 17 cases and INH in 8 cases. The clinical effect of desensitization therapy for these antituberculous drugs was good in 14 out of the 17 cases (82%) for RFP, and in 6 out of 8 cases (75 %) for INH.<BR>The effectiveness rate of the present desensitization therapy according to the guideline of the Japanese Society for Tuberculosis was almost equal to that of previous desensiti zation therapy, and the clinical results were almost same in present and previous studies despite the different methods of administration of the antituberculous drugs.

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