A clinical study of an antithrombin agent, argatroban for the prevention of platelet loss in left heart bypass with the bio-medicus centrifugal pump.

DOI 5 Citations 10 References
  • ENDO S.
    Third Department of Surgery, St. Marianna University School of Medicine Kawasaki
  • KAWADA T.
    Third Department of Surgery, St. Marianna University School of Medicine Kawasaki
  • HOZON M.
    聖マリアンナ医科大学付属東横病院外科
  • MIEDA T.
    Third Department of Surgery, St. Marianna University School of Medicine Kawasaki
  • ABE H.
    聖マリアンナ医科大学横浜市西部病院心臓血管外科
  • KIKUCHI K.
    Third Department of Surgery, St. Marianna University School of Medicine Kawasaki
  • KOYAMA T.
    Third Department of Surgery, St. Marianna University School of Medicine Kawasaki
  • KAMATA S.
    Third Department of Surgery, St. Marianna University School of Medicine Kawasaki
  • TAKEI H.
    Third Department of Surgery, St. Marianna University School of Medicine Kawasaki
  • FUNAKI S.
    Third Department of Surgery, St. Marianna University School of Medicine Kawasaki
  • YAMATE N.
    Third Department of Surgery, St. Marianna University School of Medicine Kawasaki

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Other Title
  • 遠心ポンプを用いた左心バイパス法における抗凝固療法の検討

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Abstract

Haematological effects of an antithrombin agent, argatroban was evaluated in left heart bypass (LHB) with a centrifugal pump (CFP) . From 1991 to 1994, 12 patients with thoracic or thoracoabdominal aortic disease underwent surgical treatment with a use of LHB. Patients were divided into two groups. In group A (n=6), low dose of heparin (1mg/kg, IV bolus) was administered just prior to LHB in the beginning. In Group B (n=6), argatoroban (2.5μg/kg/min) intravenously infused during LHB. Platelet count was significantly preserved after LHB in group B. β-TG and PF4 increased during LHB in the both groups, however these increases were significantly suppressed in group B. There were no significant difference in parameters of thrombogenesis between the two groups. there were no evidence of systemic thromboembolism in all patients after surgery. Platelet was effectively preserved during LHB with CFP by the use of intravenous argatroban.

Journal

  • Jinko Zoki

    Jinko Zoki 24 (2), 513-516, 1995

    JAPANESE SOCIETY FOR ARTIFICIAL ORGANS

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