溶血性尿毒症症候群脳症における経頭蓋超音波Ｄｏｐｐｌｅｒ法による経時的評価

DOI PubMed 参考文献8件

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タイトル別名
  • Perioperative Evaluation of Cerebral Hemodynamics by Transcranial Doppler Ultrasonography in Patient with Hemolytic Uremic Syndrome.

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Major central nervous system (CNS) complications such as seizures and coma, occur in about 30% of children with hemolytic uremic syndrome (HUS). Serious CNS involvement is associated with an increased mortality. The purpose of this study was to evaluate intracranial hemodynamics in HUS encephalopathy. We measured mean blood flow velocity and pulsatility index (PI) of the middle cerebral artery (MCA) with transcranial Doppler (TCD) in a two year-old girl with acute encephalopathy, and compared them to those in a one year- old girl with febrile convulsion incidentally complicating HUS (a disease control). In the patient with HUS encephalopathy TCD demonstrated abnormally low PI of 0.58, while the magnetic resonance imaging (MRI) and single-photon emission-computed tomography (SPECT) reveal no abnormal findings in the acute stage. The abnormal TCD findings disappeared with her recovery. In the HUS patient with febrile convulsion alone, TCD demonstrated normal maximal flow velocity and PI. Thus TCD may be useful in evaluating intracranial hemodynamics in HUS encephalopathy in the absence of MRI and SPECT abnormalities at the early stage of illness.

収録刊行物

  • 脳と発達

    脳と発達 32 (6), 520-523, 2000

    THE JAPANESE SOCIETY OF CHILD NEUROLOGY

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