書誌事項
- タイトル別名
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- Anxiety and Stress. Possible involvement of serotonin receptors in anxiety disorders.
- フアン ショウガイ ト セロトニン ジュヨウタイ
- 不安とストレス
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抄録
An overview of the behavioral, electrophysiological and neurochemical data found in the literature concerning the involvement of serotonin (5-HT) receptors in the regulation of anxiety was presented on the basis of animal models. At present, 5-HT receptors are classified into 7 families including at least 14 subtypes. Among these 5-HT receptors, it is conceivable that 5-HT1A-receptor-mediated effects are the most important part of the mechanism of anxiety. The demonstrated efficacy of 5-HT1A-receptor partial agonists in anxiety disorders has emphasized the importance of these receptors. Enhanced anxiety was observed in mutant mice lacking 5-HT1A receptors. In 5-HT1B receptors knockout mice, on the other hand, aggressive behavior was increased. Some of the selective antagonists acting on 5-HT2 and 5-HT3 receptors have shown the anxiolytic effects in various animal models. Inactivation of mRNA encoding 5-HT6 receptors using antisense oligonucleotide produced decreases in cortical 5-HT release enhanced by anxiety. These observations lead to the suggestion that different mechanisms, mediated by various 5-HT receptors, are involved in the pathogenesis of anxiety.
収録刊行物
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- 日本薬理学雑誌
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日本薬理学雑誌 115 (1), 39-44, 2000
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282679247939584
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- NII論文ID
- 10005705383
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- NII書誌ID
- AN00198335
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- COI
- 1:CAS:528:DC%2BD3cXhs1artw%3D%3D
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- ISSN
- 13478397
- 00155691
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- NDL書誌ID
- 4954107
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- PubMed
- 10876814
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可