A study of dilazep: II. Dilazep attenuates lysophosphatidylcholine-induced mechanical and metabolic derangements in the isolated, working rat heart
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- Hoque A.N. Ehsanul
- <I>Department of Pharmacology, Asahikawa Medical College</I>
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- Hoque Nina
- <I>Department of Pharmacology, Asahikawa Medical College</I>
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- Hashizume Hiroko
- <I>Department of Pharmacology, Asahikawa Medical College</I>
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- Abiko Yasushi
- <I>Department of Pharmacology, Asahikawa Medical College</I>
書誌事項
- タイトル別名
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- A Study on Dilazep: II. Dilazep Attenuates Lysophosphatidylcholine-Induced Mechanical and Metabolic Derangements in the Isolated, Working Rat Heart.
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The effects of dilazep, d-propranolol and lidocaine on the mechanical and metabolic changes induced by lysophosphatidylcholine (LPC) were studied in isolated, perfused working rat heart. After a stabilization period, the heart was perfused for 5 min with LPC (10 μM) alone, LPC plus dilazep (5, 10 or 20 μM), LPC plus d-propranolol (30 or 50 μM) or LPC plus lidocaine (30 or 100 μM) and then perfused with normal Krebs-Henseleit bicarbonate (KHB) buffer for a further 20 min. Perfusion with LPC for 5 min followed by KHB for 20 min irreversibly decreased cardiac mechanical function, decreased the tissue levels of adenosine triphosphate and creatine phosphate significantly, and increased the tissue levels of lactate and free fatty acids including arachidonic acid. Dilazep or d-propranolol significantly attenuated the mechanical and metabolic changes induced by LPC, but lidocaine did not. These results indicate that the exogenous LPC causes ischemia-like changes, suggesting that LPC is one of the important factors in producing ischemia-reperfusion derangements in terms of mechanical and metabolic functions, and that both dilazep and d-propranolol can prevent the LPC-induced myocardial damage.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 67 (3), 233-241, 1995
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282679263645824
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- NII論文ID
- 10005710232
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- NII書誌ID
- AA00691188
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- COI
- 1:CAS:528:DyaK2MXks1Gjtbc%3D
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- ISSN
- 13473506
- 00215198
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- PubMed
- 7630041
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可