A Possible Involvement of Monoaminergic and Opioidergic Systems in the Analgesia Induced by Electro-Acupuncture in Rabbits.
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- Takagi Jun
- Departments of Anesthesiology, Osaka University Faculty of Dentistry
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- Sawada Takanori
- Departments of Anesthesiology, Osaka University Faculty of Dentistry
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- Yonehara Norifumi
- Departments of Pharmacology, Osaka University Faculty of Dentistry
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To elucidate mechanisms involved in analgesia induced by effects of electro-acupuncture (EAP), effects of EAP on evoked potentials and release of substance P (SP) following tooth pulp stimulation (ST) in the superficial layers of the trigeminal nucleus caudalis (Vc-I-II) were studied in the rabbit. The potentials evoked by ST were composed of two main components with conduction velocity of ca. 30 m/sec (fast component) and ca. 12 m/sec (late component). The late component was significantly inhibited by morphine (10 mg/kg, i.v.) or CP-96, 345 (5 mg/kg, i.v.), an SP antagonist. This inhibitory effect of morphine was antagonized by naloxone (1 mg/kg, i.v.) or methysergide (5 mg/kg, i.v.). In addition, the late component was significantly inhibited by EAP, which was observed in ca. 70% of the rabbits examined. This EAP-induced inhibitory effect was antagonized by naloxone (1 mg/kg, i.v.) or methysergide (5 mg/kg, i.v.), but not by prazosin (5 mg/kg, i.v.) and yohimbine (1 mg/kg, i.v.). The stimulus-evoked SP release was inhibited by EAP, which was significantly antagonized by pretreatment with naloxone (1 mg/kg, i.v.) or methysergide (5 mg/kg, i.v.). These results suggest that one of the mechanisms of analgesia induced by EAP is due to inhibition of the stimulus-evoked SP release in the Vc-I-II through activation of the descending serotonergic systems linking up with opioidergic systems.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 70 (1), 73-80, 1996
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282679261634688
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- NII論文ID
- 10005713017
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- NII書誌ID
- AA00691188
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- COI
- 1:CAS:528:DyaK28XnsVynsA%3D%3D
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- ISSN
- 13473506
- 00215198
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- PubMed
- 8822091
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可