書誌事項
- タイトル別名
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- Bactericidal activity of levofloxacin in in vitro simulation system model.
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The bactericidal activity of levofloxacin (LVFX) against major respiratory pathogens was compared by using two in-vitro pharmacodynamic (PD) models with dosing simulations of 100mg every 6h and 200mg every 10h for 24h. LVFX showed bactericidal activity against two strains of Streptococcus pneumoniae with MIC of 1 and 2μg/mL in the model of 200mg b. i. d. In contrast, LVFX showed bacteriostatic activity against S. pneumoniae with MIC 2μg/mL in the 100mg t.i.d. model. The regrown S. pneumoniae after 24 h incubation was also susceptible to LVFX. Against 2 strains of Haemophilus influenzae, LVFX showed bactericidal activity in both the PD models. The MICs of H. influenzae used were 0.008 and 0.03μg/mL. LVFX also showed bactericidal activity against LVFX-susceptible Moraxella catarrhalis (LVFX MIC: 0.03 %mu;g/mL), but bacteriostatic activity was observed against a strain of M. catarrhalis (LVFX MIC: 2μg/mL). The bacteria remaining at 24h after treatment with LVFX were also susceptible to the drug. From these PD data, it is suggested that the 20-25 SIT-1·Eh of AUC/MIC of LVFX may be borderline for treating infections due to S. pneumoniae.
収録刊行物
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- 日本化学療法学会雑誌
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日本化学療法学会雑誌 48 (5), 325-332, 2000
公益社団法人 日本化学療法学会
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詳細情報 詳細情報について
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- CRID
- 1390282681264096768
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- NII論文ID
- 130004298014
- 10005860621
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- NII書誌ID
- AN10472127
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- ISSN
- 18845886
- 13407007
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可