臨床分離株のｃｅｆｄｉｔｏｒｅｎに対する感受性サーベイランス

DOI 被引用文献2件 参考文献22件

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  • Surveillance of the sensitivity of various clinical isolates to cefditoren.

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Change in the sensitivity of clinical isolates to cefditoren (CDTR) and oral cephalosporin was investigated by collecting samples in surveys over three successive time periods. In the first survey, 23 species including 805 strains were isolated from clinical materials during the 3-month period from April to June 1995. Twenty-three species 769 strains were collected during the one-year period from July 1996 to June 1997 in the second survey, and 22 species 821 strains from July 1998 to June 1999 in the third survey. The MIC distributions of CDTR and other tested drugs in each test strain that was isolated at the time of the second and third surveys demonstrated tendencies similar to those observed in the test strains isolated for the first survey. The MIC90 values of tested drugs in Streptococcus pneumoniae was higher in the second survey than in the first and third surveys. The antibacterial activity of each drug to Haemophilus influenzae in the third survey was equivalent to those in the first and second surveys. The MIC90 values of CDTR against H. influenzae were superior, 0.025-0.05μg/mL, in the tested drugs in all three surveys, but the MIC100 value rose from 0.10μg/mL in the first survey to 0.20μg/mL in the third survey. The susceptibility of various strains against tested antibiotics showed no change across all three surveys. CDTR had tsuperior activity against gram-positive and gram-negative bacteria. In particular, the activity of CDTR against bacteria isolated from respiratory infections was strong and balanced.

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