Ｆｏｓｆｏｍｙｃｉｎの抗菌作用機構の解明に関する最近の知見

• 鶴岡 勉

  明治製菓株式会社学術一部

書誌事項

タイトル別名

• Recent progress in research regarding fosfomycin: the mechanism of action and other aspects.

抄録

Fosfomycin [(-)-(1 R, 2 S)(1, 2-epoxypropyl) phosphonate] is an antimicrobial agent, which exhibits a unique mechanism of action and has been used worldwide for many years. The paper that first described the discovery of this antibiotic appeared in 1969. In Japan, its development for clinical use was started in the early 1970's, and its approval was obtained in 1980; since then fosfomycin has been used to treat many patients. Various clinical and basic reports on fosfomycin have recently appeared. One reason for this interest could be the recent approval of a new salt of fosfomycin (fosfomycin tromethamine) for clinical use in Europe and the United States of America. Moreover, at present, new data about bacterial cell wall peptidoglycan, whose synthesis is inhibited by fosfomycin have rapidly accumulated. This article is a review of recent advances in research on the mechanism of action of fosfomycin, its antimicrobial characteristics, and resistance to this antibiotic. Moreover, an outline of fosfomycin tromethamine is presented.

収録刊行物

• 日本化学療法学会雑誌

  日本化学療法学会雑誌 47 (3), 115-128, 1999

  公益社団法人 日本化学療法学会

キーワード

• 作用機構
• 抗菌特性
• 耐性

詳細情報

• CRID: 1390282681263633920
• NII論文ID: 130004297908
• NII論文ID: 10005865067
• NII書誌ID: AN10472127
• DOI: 10.11250/chemotherapy1995.47.115
• ISSN: 18845886
• ISSN: 13407007
• Web Site: https://search.jamas.or.jp/link/ui/1999180004
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可