New Anticancer Antibiotics Pelagiomicins, Produced by a New Marine Bacterium Pelagiobacter variabilis.

• IMAMURA NOBUTAKA

  Marine Biotechnology Institute, Shimizu Laboratories

• NISHIJIMA MIYUKI

  Marine Biotechnology Institute, Shimizu Laboratories

• TAKADERA TAKAHIDE

  Marine Biotechnology Institute, Shimizu Laboratories

• ADACHI KYOKO

  Marine Biotechnology Institute, Shimizu Laboratories

• SAKAI MIHO

  Marine Biotechnology Institute, Shimizu Laboratories

• SANO HIROSHI

  Marine Biotechnology Institute, Shimizu Laboratories

書誌事項

タイトル別名

• New Anticancer Antibiotics Pelagiomicin

抄録

In the course of our screening for new anticancer compounds produced by marine bacteria, we found that a new genus marine bacterium Pelagiobacter variabilis produced new phenazine antibiotics, pelagiomicins A, B and C. Those compounds were labile in water and alcohols. The absolute structure of the main component; pelagiomicin A, and the structures of the minor ones were determined from the spectroscopic data and by synthesis. Pelagiomicin A exhibits activity against Gram-positive and -negative bacteria and antitumor activity in vitro and in vivo.

収録刊行物

• The Journal of Antibiotics

  The Journal of Antibiotics 50 (1), 8-12, 1997

  公益財団法人 日本感染症医薬品協会

キーワード

• Drug Discovery
• Pharmacology

詳細情報

• CRID: 1390001204151032064
• NII論文ID: 130003503177
• NII論文ID: 10005880247
• NII書誌ID: AA0069330X
• DOI: 10.7164/antibiotics.50.8
• COI: 1:CAS:528:DyaK2sXisV2ns7k%3D
• ISSN: 18811469
• ISSN: 00218820
• NDL書誌ID: 4131803
• PubMed: 9066759
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4131803
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可