The Effects of COP-BLAM Regimen with G-CSF for Intermediate and High Grade Non-Hodgkin's Lymphoma

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  • NIITSU Nozomi
    First Department of Internal Medicine, Toho University School of Medicine
  • UMEDA Masanori
    First Department of Internal Medicine, Toho University School of Medicine

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  • 中・高悪性度非Hodgkinリンパ腫に対するG-CSF併用COP-BLAM療法の有用性
  • チュウ コウ アクセイド ヒ Hodgkin リンパシュ ニ タイスル G-CS

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Abstract

G-CSF was used concomitantly with the COP-BLAM regimen, and its therapeutic results and adverse effects were evaluated. A total of 104 patients with untreated non-Hodgkin's lymphoma (NHL), including 22 in stage II, 52 in stage III and 30 in stage IV. Seventy five patients had diffuse large cell type, 18 diffuse medium cell type, and 11 diffuse mixed cell type. The treatment consisted of the COP-BLAM regimen based on the method of Laurence et al., was performed every 3 weeks. Complete remission was achieved in 98 out of 104 patients (94.2%), and the 4-year survival rate was 82.4%, while at the time of evaluation the median observation period was 26 months. The survival time was significantly prolonged in patients with low LDH values, B-cells, stage II or low CRP values. The COP-BLAM regimen with concomitant G-CSF administration achieved a high remission rate and reduced the frequency of infections. Almost all of the patients could be treated in 21-day cycle and this appeared to be effective for treatment with increased dose intensity.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 36 (2), 84-90, 1995

    The Japanese Society of Hematology

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