アレルギー性鼻炎とその類似疾患の下気道過敏性

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  • Lower Respiratory Tract Hypersensitivity in Allergic Rhinitis and Perennial Nonallergic Rhinitis.

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Perennial rhinitis was classified as allergic rhinitis, probable allergic rhinitis, vasomotor rhinitis or eosinophilic nonallergic rhinitis. Then these various types were classified according to whether there was any difference with respect to lower respiratory tract hypersensitivity for methacholine.<BR>The various types of perennial rhinitis were identified through eosinophilic cell number in nasal smears, allergen skin testing, and IgE RIST and IgE RAST determination. In addition, we carried out a methacholine nasal provocation test using an Astograph and an allergen nasal provocative test.<BR>Lower respiratory tract hypersensitivity was determined based on respiratory resistance, spirometry and a flow-volume curve before and after methacholine inhalation through the nose.<BR>The lower respiratory tract of the subjects with perennial rhinitis showed differences in terms of methacholine hypersensitivity. Allergic rhinitis showed methacholine hypersensitivity in the entire lower respiratory tract. Probable allergic rhinitis showed hypersensitivity in the large airway. Vasomotor rhinitis showed hypersensitivity in the relative large airway. Eosinophilic nonallergic rhinitis did not show hypersensitivity in the lower respiratory tract.

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