Long-term hemodynamics and pathophysiology in a total artificial heart goat survived for 532 days with 1/R control.

• ABE Y

  Inst ef Med Electro, Faculty of Med, Univ of Tokyo

• CHINZEI T

  Inst ef Med Electro, Faculty of Med, Univ of Tokyo

• ISOYAMA T

  Aisin R & D Co. LTD

• MABUCHI K

  東京大学先端科学技術研究センターRCAST

• MATSUURA H

  東京大学先端科学技術研究センターRCAST

• BABA K

  Inst ef Med Electro, Faculty of Med, Univ of Tokyo

• KOUNO A

  Inst ef Med Electro, Faculty of Med, Univ of Tokyo

• ONO T

  Inst ef Med Electro, Faculty of Med, Univ of Tokyo

• MOCHIZUKI S

  Inst ef Med Electro, Faculty of Med, Univ of Tokyo

• SUN YP

  Inst ef Med Electro, Faculty of Med, Univ of Tokyo

• IMANISHI K

  Div of Cardiovasc Surg, Tokyo Women's Med Col Daini Hosp

• YOSHIZAWA M

  Grad Sch of Engin, Tohoku Univ

• TANAKA A

  Grad Sch of Engin, Tohoku Univ

• UCHIYAMA K

  Dep of Mech Engin, Waseda Univ

• FUJIMASA I

  東京大学先端科学技術研究センターRCAST

• ATSUMI K

  Inst ef Med Electro, Faculty of Med, Univ of Tokyo

• IMACHI K

  Inst ef Med Electro, Faculty of Med, Univ of Tokyo

Bibliographic Information

Other Title

• 完全人工心臓１／Ｒ制御による５３２日生存ヤギの長期血行動態と病態生理

Abstract

532 days survival was obtained in a total artificial heart goat with 1/R control. The stable control could be continued over the course, regardless of the pump exchanges with thrombus formation inside the pumps and the anemia caused by the bleeding from the chest pressure necrotic wound. Findings over the course of the experiment showed no hemodynamic and metabolic abnormality. Autopsy findings showed macroscopically normal in the liver. On the other hand, interesting findings such that the cardiac output did not correlate with aortic pressure, but correlate with total conductance, and the inverse relation between cardiac output and hematocrit was found in the data from within two weeks after the surgery and two weeks after the bleeding, but there was no correlation between the cardiac output and hematocrit in the other days or total protein. In conclusion, the physiologic stability of 1/R control algorithm for extended period could be demonstrated in this study.

Journal

• Jinko Zoki

  Jinko Zoki 26 (1), 21-26, 1997

  JAPANESE SOCIETY FOR ARTIFICIAL ORGANS

Keywords

• total artificial heart
• 1/R control
• cardiac output
• hemodynamics
• pathophysiology

Details

• CRID: 1390282679933179776
• NII Article ID: 10005939901
• NII Book ID: AN00120167
• DOI: 10.11392/jsao1972.26.21
• ISSN: 18836097
• ISSN: 03000818
• Web Site: https://search.jamas.or.jp/link/ui/1997155945
• Text Lang: ja
• Data Source:
  • JaLC
  • CiNii Articles
• Abstract License Flag: Disallowed