Induction of cyclooxygenase type-2 (COX-2) in rat endometrium at the peak of serum estradiol during the esterus cycle

  • Nishijima Masahiro
    Department of Obstetrics and Gynecology, Kitasato University School of Medicine
  • Katori Makoto
    Department of Pharmacology, Kitasato University School of Medicine
  • Yamamoto Shozo
    Department of Biochemistry, Tokushima University School of Medicine

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タイトル別名
  • Induction of Cyclooxygenase Type-2 (COX-2) in Rat Endometrium at the Peak of Serum Estradiol during the Estrus Cycle.

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抄録

We investigated the induction of cyclooxygenase (COX) in rat endometrium during the estrus cycle. The estrus cycle was divided into five stages (proestrus, estrus, diestrus-1, diestrus-2, diestrus-3) by cytological observation of vaginal smears. COX-1 was detected in the endometrium during all five stages of the estrus cycle. In contrast, COX-2 in the endometrium was detectable only in three stages (diestrus-3, proestrus, estrus) and showed a peak at diestrus-3, coinciding with the peak in serum estradiol level, suggesting the estradiol-dependent induction of COX-2.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 69 (3), 289-291, 1995

    公益社団法人 日本薬理学会

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