Human T Lymphotropic Virus Type I (HTLV-I)-AssociatedMyelopathy/Tropical Spastic Paraparesis (HAM/TSP). Recent Perspectives.

• IJICHI Shinji

  the Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University

• OSAME Mitsuhiro

  the Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University

抄録

Human T lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a well-defined clinicopathological entity, and approximately 1, 900 patients with HAM/TSP have been reported in the world. Improved polymerase chain reaction (PCR)-based in situ techniques have allowed a better appreciation of the cellular localization of the virus activation in infected patients, and there is accumulating evidence that HAM/TSP is characterized by a distributional bias of viral activation between the blood flow and central nervous system (CNS). This review summarizes the current status of our understanding of HAM/TSP, and emphasizes the possible pathogenic involvement of cellular interactions between infected cells and responding immunocompetent cells in the CNS of patients with HAM/TSP. In addition, the notable systemic manifestations with or without myelopathy in HTLV-I-infected individuals are described.<br>(Internal Medicine 34: 713-721, 1995)

収録刊行物

• Internal Medicine

  Internal Medicine 34 (8), 713-721, 1995

  一般社団法人 日本内科学会

キーワード

• human T lymphotropic virus type I (HTLV-I)
• myelopathy
• pathogenesis

詳細情報

• CRID: 1390282679843686272
• NII論文ID: 10006168979
• NII書誌ID: AA10827774
• DOI: 10.2169/internalmedicine.34.713
• COI: 1:STN:280:BymD1cros1Y%3D
• ISSN: 13497235
• ISSN: 09182918
• PubMed: 8563108
• Web Site: http://www.jstage.jst.go.jp/article/internalmedicine1992/34/8/34_8_713/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1996079762
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可