Characterization of Distribution of T Lymphocyte Subsets and Activated T Lymphocytes Infiltrating into Sarcoid Lesions.
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- KITA Shinji
- the Third Department of Internal Medicine, Oita Medical University
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- TSUDA Tomiyasu
- the Third Department of Internal Medicine, Oita Medical University
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- SUGISAKI Katsunori
- the Third Department of Internal Medicine, Oita Medical University
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- MIYAZAKI Eishi
- the Third Department of Internal Medicine, Oita Medical University
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- MATSUMOTO Tetsuro
- the Third Department of Internal Medicine, Oita Medical University
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We studied the relationship between various T lymphocyte functions and granuloma formation in 5 lung tissue and 4 lymph node tissue samples from patients with sarcoidosis by immunohistological methods. In the lesion of sarcoidosis, T cells were positive for αβTCR, but γβTCR-positive T cells were rarely observed. The results of analysis of functional subsets showed that T cells in the internal area of granuloma were predominantly helper/inducer subset (CD4+ CD45RA-). On the other hand, cytotoxic T cells (CD8+CD45RA-CD11b-) were present in abundance in the outer boundaries of granuloma. In addition, suppressor-inducer T cells (CD4+CD45R A+) were present in the surrounding areas. However, T cells of various subsets were present sporadically outside the granulomas. We also studied the distribution of T cells expressing activation-related antigens. The results showed that T lymphocytes in the internal area of granulomas more frequently had these antigens than did T lymphocytes in the external area. These findings suggested that T cells infiltrating into the sarcoidosis lesion demonstrated a layer-like distribution based on functional subsets. These findings also confirm that activated T cells were more abundantly distributed in the internal area of sarcoid granuloma than in the external area.<br>(Internal Medicine 34: 847-855, 1995)
収録刊行物
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- Internal Medicine
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Internal Medicine 34 (9), 847-855, 1995
一般社団法人 日本内科学会
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詳細情報 詳細情報について
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- CRID
- 1390282679846356736
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- NII論文ID
- 10006169681
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- NII書誌ID
- AA10827774
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- COI
- 1:STN:280:BymC387msVM%3D
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- ISSN
- 13497235
- 09182918
- http://id.crossref.org/issn/09182918
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- PubMed
- 8580555
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可