わが国における肺好酸球性肉芽腫症　１７症例についての臨床的分析

DOI PubMed 被引用文献14件 参考文献20件
  • 浅本 仁
    国立京都病院呼吸器内科
  • 北市 正則
    京都大学胸部疾患研究所附属病院検査部
  • 長井 苑子
    京都大学胸部疾患研究所臨床免疫学・呼吸器内科
  • 西村 浩一
    京都大学胸部疾患研究所環境呼吸器病学・呼吸器内科
  • 伊藤 春海
    京都大学医学部附属病院放射線部
  • 泉 孝英
    京都大学胸部疾患研究所環境呼吸器病学・呼吸器内科

書誌事項

タイトル別名
  • Pulmonary Eosinophilic Granuloma. Clinical Analysis of 17 Patients.
  • Clinical Analysis of 17 Patients
  • 17症例についての臨床的分析

この論文をさがす

抄録

We studied the clinical features of 17 Japanese patients with pulmonary eosinophilic granuloma. Fourteen of the patients were men and three were women; they ranged in age from 19 to 64 years, with a mean of 34 years at the time of the first examination. Pathologic diagnosis in all patients was based on histologic findings of specimens obtained by open lung biopsy.<br>Major symptoms were dry or productive cough, chest pain, dyspnea, and fever; 23.3% of the patients were asymptomatic. Five patients had pneumothorax. Most patients did not have abnormal physical signs. All 17 patients had histories of smoking, and 14 had started to smoke cigaretts before the age of 20 years.<br>Ten patients (58.8%) first presented with cough or dyspnea, and in the other patients (41.2%) the first abnormalities detected were pulmonary infiltrates on chest radiographs during health examinations.<br>Chest roentgenograms usually showed bilateral abnormalities. These abnormalities were distributed over all lung fields in 9 cases (52.9%), in the upper and middle lung fields in 4 cases (23.5%) in the upper lung fields in 3 cases (17.7%), and in the middle lung fields in 1 case (5.9%). Micronodular, reticular, cystic or linear shadows were evident in most cases, and were mixed in various proportions. Eleven patients (65%) had abnormalities of pulmonary function. Low %VC and %FEV1 and high RV/TLC ratios were observed in 20-40% of the patients. Low DLCOs (%DLCO<70%) were observed in 53% of the patients. Arterial blood gases were normal in 11 of 15 patients.<br>The extent of shadows in the chest roentgenogram was related to the frequency of dyspnea, to the total number of cells in bronchoalveolar lavage fluid, and to the abnormally low %FVC and %FEV1 but not to the % DLCO.<br>Data from bronchoalvealor lavage fluid were non-specific in this disease, but further studies will be needed.<br>Follow-up data were collected on 16 patientss. The mean time from the histologic diagnosis after open lung biopsy to the last observation was 81.8 ± 45.1 months (range, 2 months to 15 years). One patient died of pulmonary eosinophilic granuloma. The usefullness of steroid therapy remains uncertain.

収録刊行物

被引用文献 (14)*注記

もっと見る

参考文献 (20)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ