書誌事項
- タイトル別名
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- Antinociceptive effects of Kami-kihi-to in mice.
- マウス ニ オケル カミ キ ヒ トウ ノ コウ シンガイ ジュヨウ サヨウ
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Oral administration of Kami-kihi-to (KMK) dose-dependently inhibited the response to acetic acid-induced writhing in mice. The KMK-induced antinociceptive action was reduced by pretreatment with yohimbine, an α2-adrenergic antagonist, or cyproheptadine, a serotonergic antagonist, but not naloxone, an opiate antagonist. The antinociceptive action of KMK was clearly reduced by pretreatment with α-methyl-DL-p-tyrosine, reserpine or p-chlorophenylalanine or by simultaneous treatment with diethyldithiocarbamate, all of which are monoamine synthetic inhibitors or monoamine depletors. After spinal transection, the antinociceptive effect of KMK was markedly reduced. These findings suggest that the antinociceptive action of KMK may be related to pain inhibitory systems such as the serotonergic and noradrenergic systems at the supraspinal level.
収録刊行物
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- 日本薬理学雑誌
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日本薬理学雑誌 108 (2), 77-83, 1996
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282679248620928
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- NII論文ID
- 10006201458
- 10010924977
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- NII書誌ID
- AN00198335
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- COI
- 1:STN:280:BymH38rivVY%3D
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- ISSN
- 13478397
- 00155691
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- NDL書誌ID
- 4005951
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- PubMed
- 8827725
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可