経過中に抗好中球細胞質抗体陽性の半月体形成性糸球体腎炎を発症した間質性肺炎の1例

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  • Chronic Interstitial Pneumonia and Crescentic Glomerulonephritis Associated with Perinuclear Antineutrophil Cytoplasmic Antibodies.

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We examined a 72-year-old man suffering from chronic interstitial pneumonia with crescentic glomerulonephritis associated with perinuclear antineutrophil cytoplasmic antibodies (P-ANCA). Ten years before admission, he was given a diagnosis of interstitial pneumonia, but received no medication. He was admitted to our hospital because of a high fever and back pain. Antibiotics were used, but without success. The serum P-ANCA titer was high, and examination of a kidney biopsy specimen showed crescentic glomerulonephritis. Computed tomography of the chest showed that the lungs had a honecomblike appearance, and examination of a specimen obtained by transbronchial lung biopsy showed interstitial fibrosis. This case shows that interstitial pneumona can be associated with P-ANCA. It is important to be a wore that crescentic glomerulonephritis associated with P-ANCA can develop in patients with interstitial pneumonia.

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