A Simple Spectrophotometric Determination of Some Phenothiazine Drugs in Pharmaceutical Samples.
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- NAGARAJA Padmarajaiah
- Department of Chemistry, University of Mysore
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- DINESH Nandipura D.
- Department of Chemistry, University of Mysore
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- GOWDA Netkal M. MADE
- Department of Chemistry, Western Illinois University
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- RANGAPPA Kanchugarakoppal S.
- Department of Chemistry, University of Mysore
書誌事項
- タイトル別名
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- Simple Spectrophotometric Determination of Some Phenothiazine Drugs in Pharmaceutical Samples
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A new, simple and sensitive spectrophotometric method for the determination of some phenothiazine drugs has been developed. The proposed method is based on the reaction of promethazine hydrochloride (PH), chlorpromazine hydrochloride (CPH), triflupromazine hydrochloride (TPH), fluphenazine hydrochloride (FPH), trifluoperazine hydrochloride (TFPH), perazine dimaleate (PDM) and prochlorperazine maleate (PCPM) with iron(III) and a subsequent reaction with ferricyanide in an acetic acid medium to yield Prussian blue colored product with a maximum absorption at 700-720 nm. The common excipients used as additives in pharmaceuticals do not interfere with the proposed method. Analytical data for determination of the pure compound are presented together with the applications of the proposed method to the analysis of some pharmaceutical formulations. The results compare favorably with those of the official method.
収録刊行物
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- Analytical Sciences
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Analytical Sciences 16 (11), 1127-1131, 2000
社団法人 日本分析化学会
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詳細情報 詳細情報について
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- CRID
- 1390001204255322496
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- NII論文ID
- 10006675852
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- NII書誌ID
- AA10500785
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- COI
- 1:CAS:528:DC%2BD3cXosF2gurg%3D
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- ISSN
- 13482246
- 09106340
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- NDL書誌ID
- 5571816
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- Web Site
- https://ndlsearch.ndl.go.jp/books/R000000004-I5571816
- https://link.springer.com/content/pdf/10.2116/analsci.16.1127.pdf
- https://link.springer.com/article/10.2116/analsci.16.1127/fulltext.html
- http://www.jstage.jst.go.jp/article/analsci/16/11/16_11_1127/_pdf
- https://search.jamas.or.jp/link/ui/2001073732
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- 本文言語コード
- en
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