Cytokine upregulation in tubulointerstitial nephritis associated with membranous nephropathy

• Wada, Takashi

• Yokoyama, Hitoshi

• Sakai, Norihiko

• Izumiya, Yoshiaki

• Shimizu, Miho

• Furuichi, Kengo

• Segawa, Chikako

• Misaki, Tsuguho

• Kobayashi, Ken-ichi

抄録

We describe the upregulation of cytokines in a 45-year-old woman with tubulointerstitial nephritis and membranous nephropathy revealed by renal biopsy. She was treated with a combination of prednisolone and cyclosporin. Histological findings showed appreciable improvement, and urinary protein excretion was decreased from 15 g/day to 1 g/day. Elevated urinary levels of chemokines, interleukin (IL)-8 and monocyte chemotactic and activating factor (MCAF)/monocyte chemoattractant protein (MCP)-1, and serum levels of tumor necrosis factor (TNF)-α decreased during convalescence; 13 other patients with membranous nephropathy did not show elevation of these cytokines. These results suggest that the upregulation of these cytokines may participate in the pathogenesis of tubulointerstitial nephritis and that combination therapy of prednisolone and cyclosporin may be effective, possibly via inducing a decrease in these cytokines.

収録刊行物

• Clinical and Experimental Nephrology

  Clinical and Experimental Nephrology 3 (2), 130-132, 1999-01-01

  日本腎臓学会 = Japanese Society of Nephrology

キーワード

• Chemokine
• Cytokine
• Membranous nephropathy
• Tubulointerstitial nephritis

詳細情報

• CRID: 1050001335950805888
• NII論文ID: 10006834212
• NII書誌ID: AA11126935
• ISSN: 13421751
• Web Site: http://hdl.handle.net/2297/29243
• Web Site: https://search.jamas.or.jp/link/ui/1999260638
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles