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- 山口 惠三他
- 東邦大学医学部微生物学教室
書誌事項
- タイトル別名
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- Susceptibility of clinical isolates from Japan to trovafloxacin and other antimicrobial agents.
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The susceptibility of 2, 197 clinical isolates in Japan to trovafloxacin and other antimicrobial agents was determined by broth microdilution. Test strains were isolated from 1997 to 1999 from patients with bacterial infections other than urinary tract infections at 14 hospitals in Japan. The activity of trovafloxacin against gram-positive organisms was greater than that of ciprofloxacin, tosufloxacin, sparfloxacin, levofloxacin or cephems. MIC90 of trovafloxacin against methicillin-susceptible Staphylococcus aureus was 0.03μg/mL, of Streptococcus pyogenes 0.25μg/mL, of Streptococcus pneumoniae 0.25μg/mL and Streptococcus agalactiae 0.5μg/mL. Trovafloxacin exhibited great activity against S.pneumoniae, regardless of penicillin resistance. Although trovafloxacin and other fluoroquinolones exhibited low activity against Enterococcus faecalis and Enterococcus faecium, trovafloxacin (MIC90, 2μg/mL) was more active against Enterococcus avium than other agents. The activity of trovafloxacin (MIC90s, 0.12 to 1μg/mL) against Escherichia coli, Klebsiella pneumoniae, Citrobacter freundii, Enterobacter aerogenes, Proteus vulgaris, and Morganella morganii was comparable to or greater than that of cephems and imipenem. Trovafloxacin and other fluoroquinolones (MIC90s, ≤0.015 to 0.06μg/mL) exhibited great activity against Moraxella catarrhalis and Haemophilus influenzae. Fluoroquinolones (MIC90s, 4 to 8μg/mL) including trovafloxacin were more active against Pseudomonas aeruginosa than other agents. Trovafloxacin was the most active against Bacteroides fragilis with an MIC90 of 2μg/mL.
収録刊行物
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- 日本化学療法学会雑誌
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日本化学療法学会雑誌 49 (4), 241-256, 2001
公益社団法人 日本化学療法学会
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詳細情報 詳細情報について
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- CRID
- 1390001206286905088
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- NII論文ID
- 130004298062
- 10006989746
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- NII書誌ID
- AN10472127
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- ISSN
- 18845886
- 13407007
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可