1999年の複雑性尿路感染症患者分離株の薬剤感受性

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  • Antimicrobial susceptibilities of organisms isolated from patients with complicated urinary tract infections in 1999.

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Using the agar dilution method, the susceptibility of Staphylococcus aureus (including MRSA), Enterococcus faecalis, Escherichia coli and Pseudomonas aeruginosa, to various antimicrobial agents was examined. All strains were isolated from patients with complicated urinary tract infections (UTIs) who visited the Department of Urology at Kagoshima University Hospital, between January and December 1999. An inoculum size of 106 CFU/mL was used. Vancomycin exhibited the most potent antibacterial activity against S.aureus and E.faecalis, with an MIC90 of 1.56μg/mL. All carbapenems showed potent antibacterial activity against E.faecalis, with an MIC90 of less than 12.5μg/mL. All carbapenems and most of the cephems exhibited potent antibacterial activities against E.coli, with that of meropenem (MEPM) being especially high (the MIC90 was less than 0.025μg/mL). MEPM exhibited the strongest antibacterial activity against P.aeruginosa, with an M1C90 of 3.13μg/mL. In a regression analysis, positive correlations were observed between the MICs of MEPM and imipenem (IPM), MEPM and panipenem (PAPM), and IPM and PAPM in the tested strains. The correlation coefficients ranged between 0.753 and 0.995. A comparison of the MICs of carbapenems against S.aureus, E.faecalis, E.coli and P.aeruginosa strains isolated between 1997 and 1998 and urinary isolates obtained in 1999, showed no tendency towards drug resistance in the uroisolates.

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