Deep White Matter Lesions on MRI, and Not Silent Brain Infarcts Are Related to Headache and Dizziness of Non-specific Cause in Non-Stroke Japanese Subjects.

• FUJISHIMA Masatoshi

  the Second Department of Internal Medicine, Kyushu University

• YAO Hiroshi

  the Second Department of Internal Medicine, Kyushu University

• TERASHI Akiro

  the Second Department of Internal Medicine, Nippon Medical School

• TAGAWA Koichi

  the Department of Internal Medicine, National Fukuoka Higashi Hospital

• MATSUMOTO Masayasu

  the First Department of Internal Medicine, Osaka University Medical School

• HARA Hitoshi

  the Cerebrovascular Division, Department of Internal Medicine, National Cardiovascular Center

• AKIGUCHI Ichiro

  the Department of Neurology, Kyoto University

• SuzuKi Kazuo

  the Department of Epidemiology, Akita Research Institute of Brain and Blood Vessels

• NISHIMARU Katsuya

  The First Department of Internal Medicine, Fukuoka University

• UDAKA Fukashi

  the Department of Neurology, Sumitomo Hospital

• GYOTEN Tetsuya

  the Department of Neurosurgery, Zentsuji National Hospital

• TAKEUCHI Juji

  the Department of Neurosurgery, National Utano Hospital

• HAMADA Rikuzo

  the Department of Neurology, Minamikyushu-Chuo National Hospital

• YosHiDA Yoji

  the First Department of Pathology, Yamanashi Medical University

• IBAYASHI Setsuro

  the Second Department of Internal Medicine, Kyushu University

抄録

Objective Silent or asymptomatic cerebrovascular disease is believed to be an important risk factor for symptomatic stroke and vascular dementia. Although non-specific complaints such as mild to moderate headache and/or dizziness may also be caused by silent stroke, which remains a topic of controversy.<br> Methods To investigate the relationship between silent brain infarcts and non-specific complaints, we assessed findings on magnetic resonance images using a common protocol in the following three groups of subjects; Group 1: 78 subjects with non-specific complaints, Group 2:47 subjects with vascular risk factors, and Group 3: 75 normal subjects without any subjective complaints or vascular risk factors. In addition to silent stroke, deep white matter lesions on MRI were also evaluated. All subjects were recruited from 12 institutes of the study group located at various parts of Japan.<br> Results Silent brain infarcts were demonstrated in 44 %, 43%, and 20% of subjects in Groups 1, 2, and 3, respectively. In Group 1, the average number of infarcts per individual who had silent brain infarction was 1.8, which was significantly fewer than 3.8 in Group 2 or 3.5 in Group 3 (p<0.0167). White matter lesions were found in 68%, 49%, and 11% in Groups 1, 2, and 3, respectively, indicating that non-specific complaints are more closely related to deep white matter lesions than to silent infarct lesions. Such white matter lesions were found more frequently in subjects with depressive state than in non-depressed subjects (67% vs. 39%, p=0.0155).<br> Conclusion The present results suggest that deep white matter lesions, rather than silent brain infarcts, appear to be important in producing headache and/or dizziness of non-specific cause and also to be related to the depressive state.<br>(Internal Medicine 39: 727-731, 2000)

収録刊行物

• Internal Medicine

  Internal Medicine 39 (9), 727-731, 2000

  一般社団法人 日本内科学会

キーワード

• asymptomatic cerebrovascular disease
• hypertension
• aging
• non-specific complaints
• leukoaraiosis

詳細情報

• CRID: 1390001204869007104
• NII論文ID: 10006996241
• NII書誌ID: AA10827774
• DOI: 10.2169/internalmedicine.39.727
• COI: 1:STN:280:DC%2BD3M%2FktlKjtQ%3D%3D
• ISSN: 13497235
• ISSN: 09182918
• NDL書誌ID: 5501704
• PubMed: 10969904
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I5501704
• Web Site: http://www.jstage.jst.go.jp/article/internalmedicine1992/39/9/39_9_727/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2001014020
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可