Reversibility of Serum NH3 Level in a Case of Sudden Onset and Rapidly Progressive Case of Type 2 Citrullinemia.

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  • ISHIKAWA Fumihiko
    the Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University
  • NAKAMUTA Makoto
    the Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University
  • KATO Masaki
    the Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University
  • IWAMOTO Hiroaki
    the Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University
  • ENJOJI Munechika
    the Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University
  • MIYATA Yasuji
    Miyata Medical Clinic
  • INOGUCHI Toyoshi
    the Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University
  • SAKAI Hironori
    the Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University
  • NAWATA Hajime
    the Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University

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A 48-year-old male presented with an acute change in mental status due to a marked elevation of plasma NH3 and was diagnosed with citrullinemia with amino acid analysis of blood. Hemodialysis and hemodiafiltration were performed, but serum chemical analysis did not show any improvement which led us to terminate dialysis following intensive care for 3 days. Surprisingly, NH3 level had decreased by 6 days after admission, coinciding with normalization of the size of the pupils. Since spontaneous remission had never been discussed, we discuss this relatively rare, but clinically significant entity with regard to its acute phase management and its potential reversibility.<br>(Internal Medicine 39: 925-929, 2000)

収録刊行物

  • Internal Medicine

    Internal Medicine 39 (11), 925-929, 2000

    一般社団法人 日本内科学会

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