Serious Arrhythmias in Patients with Apical Hypertrophic Cardiomyopathy.

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  • OKISHIGE Kaoru
    the Department of Cardiovascular Disease, Yokohama Red Cross Hospital
  • SASANO Tetsuo
    the Department of Cardiovascular Disease, Yokohama Red Cross Hospital
  • YANO Kei
    the Department of Cardiovascular Disease, Yokohama Red Cross Hospital
  • AZEGAMI Kouji
    the Department of Cardiovascular Disease, Yokohama Red Cross Hospital
  • SUZUKI Kou
    the Department of Cardiovascular Disease, Yokohama Red Cross Hospital
  • ITOH Kuniyasu
    the Department of Radiology, Yokohama Red Cross Hospital

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We report cases of serious arrhythmias associated with apical hypertrophic cardiomyopathy (AHCM). Thirty-one patients were referred to our institute to undergo further assessment of their AHCM from 1988 to 1999. Three patients with nonsustained ventricular tachycardia demonstrated an 123I-MIBG regional reduction in the tracer uptake. In two patients with ventricular fibrillation (VF), the findings from 123I-MIBG imaging revealed regional sympathetic denervation in the inferior and lateral regions. Electrophysiologic study demonstrated reproducible induction of VF in aborted sudden death and presyncopal patients, resulting in the need for an implantable defibrillator device and amiodarone in each patient. Patients with refractory atrial fibrillation with a rapid ventricular response suffered from serious congestive heart failure. A prudent assessment and strategy in patients with this disease would be indispensable in avoiding a disastrous outcome.<br>(Internal Medicine 40: 396-402, 2001)

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  • Internal Medicine

    Internal Medicine 40 (5), 396-402, 2001

    一般社団法人 日本内科学会

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