Adrenocorticotropin-Independent Macronodular Adrenocortical Hyperplasia Associated with Multiple Colon Adenomas/Carcinomas Which Showed a Point Mutation in the APC Gene.
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- YAMAKITA Noriyoshi
- The Department of Internal Medicine, Matsunami General Hospital
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- MURAI Toshihiro
- The Department of Internal Medicine, Matsunami General Hospital
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- ITO Yasufumi
- The Department of Internal Medicine, Matsunami General Hospital
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- MIURA Kiyoshi
- Clinical Research Center of Endocrinology and Metabolism, Matsunami General Hospital
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- IKEDA Tsuneko
- The Department of Pathology, Matsunami General Hospital
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- MIYAMOTO Kohji
- The Department of Surgery, Matsunami General Hospital
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- ONAMI Shumpei
- Genetics Division, National Cancer Center Research Institute
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- YOSHIDA Teruhiko
- Genetics Division, National Cancer Center Research Institute
書誌事項
- タイトル別名
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- Adrenocorticotropin-Independent Macrono
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抄録
We report a male Japanese with corticotropin (ACTH)-independent macronodular adrenocortical hyperplasia (AIMAH) associated with multiple colon adenomas/carcinomas. The plasma cortisol level was elevated with no diurnal rhythm and was not suppressed with dexamethasone. Basal plasma ACTH was unmeasurable but subnormally increased after administration of metyrapone or corticotropin releasing hormone. Both adrenals were resected and weighed 90g; the histopathologic findings were similar to those of AIMAH as previously reported. At least 21 colon lesions which were adenomas or carcinomas, were resected endoscopically or surgically. This is the second reported case of the association of AIMAH with multiple colon polyps. An APC gene point mutation was detected in the colon cancer tissue by polymerase chain reaction (PCR)-single strand conformation polymorphism (SSCP)/direct sequencing analysis at the putative splice acceptor site consensus sequence. However, no abnormality of APC gene was detected in the adrenocortical hyperplastic tissue. The possible etiological coexistence of these two diseases is discussed.<br>(Internal Medicine 36: 536-542, 1997)
収録刊行物
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- Internal Medicine
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Internal Medicine 36 (8), 536-542, 1997
一般社団法人 日本内科学会
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詳細情報 詳細情報について
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- CRID
- 1390001204869750016
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- NII論文ID
- 10007007216
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- NII書誌ID
- AA10827774
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- COI
- 1:CAS:528:DyaK2sXmt1yitrk%3D
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- ISSN
- 13497235
- 09182918
- http://id.crossref.org/issn/09182918
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- NDL書誌ID
- 4270755
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- PubMed
- 9260769
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可