Incidence and Characteristics of Thyroid Dysfunction Following Interferon Therapy in Patients with Chronic Hepatitis C.

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  • AMENOMORI Masahiro
    The Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine
  • MORI Toru
    The Department of Laboratory Medicine, Faculty of Medicine, Kyoto University
  • FUKUDA Yoshihiro
    The Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine
  • SUGAWA Hideo
    The Department of Laboratory Medicine, Faculty of Medicine, Kyoto University
  • NISHIDA Naoshi
    The Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine
  • FURUKAWA Motonobu
    The Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine
  • KITA Ryuichi
    The Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine
  • SANDO Takehiro
    The Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine
  • KOMEDA Toshiki
    The Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine
  • NAKAO Kazuwa
    The Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine

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  • Incidence and Characteristics of Thyroi

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Thyroid functions were analyzed before, during and after interferon (IFN) therapy in patients with chronic hepatitis C. According to the results of routine thyroid function tests and measurements of the levels of anti-thyroid autoantibody prior to the therapy, patients were divided into 2 groups; Group A (19 patients) had at least one abnormal finding related to the thyroid, and Group B (40 patients) did not show any abnormality. Five patients (26% ) in Group A and 4 (10%) in Group B showed thyroid dysfunctions which were very clearly reflected by thyrotropin (TSH) measurements. Interestingly, the time of peak TSH elevation in Group A (mean±SD, 4.3±0.8 months) was significantly earlier than that in Group B (6.8±0.8). Most patients in Group B were diagnosed as having destructive thyroiditis. These findings may suggest that the pathogenesis of IFN-induced thyroid dysfunction consists not only of exacerbation of pre-existing thyroid autoimmunity but also of de novo destructive changes even in the intact thyroid before IFN therapy.<br>(Internal Medicine 37: 246-252, 1998)

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  • Internal Medicine

    Internal Medicine 37 (3), 246-252, 1998

    一般社団法人 日本内科学会

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