Diffuse Panbronchiolitis and Rheumatoid Arthritis-Associated Bronchiolar Disease: Similarities and Differences.

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  • HAYAKAWA Hiroshi
    The Department of Internal Medicine, National Sanatorium Tenryu Hospital The Second Department of Internal Medicine, Hamamatsu University School of Medicine
  • SATO Atsuhiko
    The Second Department of Internal Medicine, Hamamatsu University School of Medicine
  • IMOKAWA Shiro
    The Second Department of Internal Medicine, Hamamatsu University School of Medicine
  • TODATE Akihito
    The Second Department of Internal Medicine, Hamamatsu University School of Medicine
  • CHIDA Kingo
    The Second Department of Internal Medicine, Hamamatsu University School of Medicine
  • SUZUKI Kazuya
    The First Department of Surgery, Hamamatsu University School of Medicine
  • IWATA Masatoshi
    The Department of Respiratory Medicine, Haibara General Hospital

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タイトル別名
  • Diffuse Panbronchiolitis and Rheumatoid

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There is a considerable overlap between diffuse panbronchiolitis (DPB) and bronchiolar disease associated with rheumatoid arthritis. The present study assessed how these conditions could be differentiated. The subjects included 25 DPB patients and 15 RA patients with bronchiolar disease (RA-BD). Patients with either condition had chronic cough, purulent sputum, dyspnea and coarse crackles. Most patients with either DPB or RA-BD had a history of sinusitis as well as elevated cold hemagglutin titers and decreased levels in partial pressure of oxygen (PaO2), forced expiratory volume in one second (FEV1.0) and V 25/Ht. On histological examination, both conditions also shared various histological patterns although panbronchiolitis lesions were more common in DPB than RA-BD (68% vs 20%) and bronchiolar obliteration appeared to occur at more proximal sites in RA-BD than DPB. However, there were important differences: long-term treatment with erythromycin had less effect in RA-BD than DPB, and the frequency of HLA B54 tended to be higher in DPB than RA-BD (50.0% vs 22.2%), suggesting that they are distinct conditions.<br>(Internal Medicine 37: 504-508, 1998)

収録刊行物

  • Internal Medicine

    Internal Medicine 37 (6), 504-508, 1998

    一般社団法人 日本内科学会

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