Hydroxyureaによる治療中にβ‐thalassemia minorの合併が確認された慢性骨髄性白血病

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タイトル別名
  • .BETA.-Thalassemia Minor Diagnosed in a Patient with Chronic Myelogenous Leukemia during Hydroxyurea Therapy.
  • Hydroxyureaによる治療中にβ-thalassemia minorの合併が確認された慢性骨髄性白血病
  • Hydroxyurea ニ ヨル チリョウ チュウ ニ ベーターthalassemia minor ノ ガッペイ ガ カクニン サレタ マンセイ コツズイセイ ハッケツビョウ

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抄録

A 55-year-old man was admitted to our hospital because of leukocytosis and microcytic anemia with hypochromia, target cells, and increased levels of hemoglobin A2 and hemoglobin F. The results of a gene analysis yielded a diagnosis of chronic myelogenous leukemia and β-thalassemia minor. A gradual increase in hemoglobin was observed during hydroxyurea therapy, which was performed over a 12-week period. This increment appeared to be due to suppressed production of myeloid cells. It has been reported that hydroxyurea increases total hemoglobin due to increased hemoglobin F synthesis in patients with β-thalassemia. However, hydroxyurea had no clear influence on hemoglobin concentration in this case.

収録刊行物

  • 臨床血液

    臨床血液 41 (1), 61-64, 2000

    一般社団法人 日本血液学会

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