プロトンポンプ阻害薬を服用中にカンジダ食道炎を発症した３症例の検討

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  • Three cases of candida esophagitis, diagnosed during treatment with a proton pump inhibitor.

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We report 3 cases of candida esophagitis, diagnosed during treatment with a proton pumpinhibitor, lansoprazole. Before treatment, all of them had gastric ulcer but none had candidaesophagitis. Candida esophagitis was diagnosed at the end of initial treatment with 8 weeks oflansoprazole in two cases. In the third case, diagnosis of candida esophagitis was made at theend of maintenance treatment of weekly administration of lansoprazole for 6 months. No casehad symptoms referable to candida esophagitis and all of them recovered from it simply bystopping to take lansoprazole. Lansoprazole may have caused candida esophagitis throughmechanisms other than acid inhibition. Because, it was unlikely that acidity in stomach andesophagus was continuously suppressed for one week in the last case.

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