重症心身障害児・者に合併するてんかんの長期予後

• 林 優子

  旭川荘療育センター児童院小児科

• 花田 華名子

  旭川荘療育センター児童院小児科

• 堀内 伊作

  旭川荘療育センター児童院小児科

• 諸岡 美知子

  旭川荘療育センター児童院小児科

• 山磨 康子

  旭川荘療育センター児童院小児科 岡山県立大学保健福祉学部保健福祉学科

書誌事項

タイトル別名

• Epilepsy in Patients with Severe Motor and Intellectual Disabilities: a Long-Term Follow-Up.

抄録

Long-term prognosis of epilepsy was investigated on 117 institutionalized patients with severe motor and intellectual disabilities, who were above 15 years of age in 1977, for a 20-year-period from 1977 to 1997. The incidence of epilepsy was 64.1%(75 patients), which was active in 28 patients (37.3%). The patients with the most severe psychomotor disabilities (bedridden and DQ<20) showed the highest incidence of epilepsy (85.0%). Patients who died during the follow-up period showed higher incidence of active epilepsy (p<0.01).<BR>During the follow-up of 94 surviving patients, persistence, relapse, and onset of seizures were frequent in patients with most severe intellectual disability, whereas those with less severe intellectual disability (20<DQ<35) were all seizure-free. Twenty-one patients had active epilepsy; symptomatic partial epilepsy in 17 (81.0%) and generalized epilepsy in 4 (19.0%). Notably, 5 of the 6 patients with persistent frequent seizures had age- dependent epileptic encephalopathy; persistent Lennox-Gastaut syndrome (LGS) (2 patients), severe epilepsy with multiple independent spike foci evolved from West syndrome (WS) and LGS (2 patients), and partial epilepsy with the history of LGS (1 patient).

収録刊行物

• 脳と発達

  脳と発達 33 (5), 416-420, 2001

  THE JAPANESE SOCIETY OF CHILD NEUROLOGY

キーワード

• 重症心身障害児・者
• てんかん合併率
• 活動性てんかん
• 難治率
• 長期予後

詳細情報

• CRID: 1390001204552126464
• NII論文ID: 130004183498
• NII論文ID: 10007101995
• NII書誌ID: AN0020232X
• DOI: 10.11251/ojjscn1969.33.416
• ISSN: 18847668
• ISSN: 00290831
• PubMed: 11558144
• Web Site: https://search.jamas.or.jp/link/ui/2002064981
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可