Antinociceptive Effect of Vitamin K2 (Menatetrenone) in Diabetic Mice.

• Onodera Kenji

  Department of Dental Pharmacology, Okayama University Dental School

• Zushida Ko

  Department of Pathophysiology & Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University

• Kamei Junzo

  Department of Pathophysiology & Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University

抄録

The antinociceptive effect of vitamin K₂ (menatetrenone) in diabetic mice was examined using a tail-pressure test. Intraperitoneal injection of menatetrenone (10 - 100 mg/kg) produced a dose-dependent increase in the nociceptive threshold in diabetic mice. There was no significant difference between non-diabetic and diabetic mice in the menatetrenone-induced changes in the nociceptive threshold. The results suggest the therapeutical usefulness of menatetrenone for treating painful diabetic neuropathy and osteoporosis.

収録刊行物

• Jpn.J.Pharmacol.

  Jpn.J.Pharmacol. 85 (3), 335-337, 2001

  公益社団法人 日本薬理学会

キーワード

• Vitamin K₂ (menatetrenone)
• Antinociception
• Painful diabetic neuropathy

詳細情報

• CRID: 1390282679264244352
• NII論文ID: 10007120610
• NII書誌ID: AA00691188
• DOI: 10.1254/jjp.85.335
• COI: 1:CAS:528:DC%2BD3MXitlSlsLY%3D
• ISSN: 13473506
• ISSN: 00215198
• NDL書誌ID: 5714779
• PubMed: 11325029
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I5714779
• Web Site: https://api.elsevier.com/content/article/PII:S002151981930438X?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S002151981930438X?httpAccept=text/plain
• Web Site: https://search.jamas.or.jp/link/ui/2001181467
• 本文言語コード: en
• データソース種別:
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  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
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