Possible Roles of Cardiac Chymase After Myocardial Infarction in Hamstar Hearts
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- Jin Denan
- Department of Pharmacology, Osaka Medical College
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- Takai Shinji
- Department of Pharmacology, Osaka Medical College
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- Yamada Mayumi
- Department of Pharmacology, Osaka Medical College
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- Sakaguchi Masato
- Department of Pharmacology, Osaka Medical College
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- Yao Yulin
- Discovery Research Division, Santen Pharmaceutical Co., Ltd.
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- Miyazaki Mizuo
- Department of Pharmacology, Osaka Medical College
書誌事項
- タイトル別名
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- Possible Roles of Cardiac Chymase After Myocardial Infarction in Hamster Hearts.
- Possible roles of cardiac chymase after myocardial infarction in hamster
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抄録
The significance of cardiac chymase after myocardial infarction (MI) was evaluated using a hamster model of MI. At 1, 3, 7, 14, 28 and 56 days after MI, tissues were removed for measurements of angiotensin-converting enzyme (ACE) and chymase activities. The mean infarct size 3 days after left coronary artery ligation was 47.3 ± 5.9% of the left ventricle circumference. The ratio of left ventricle weight to body weight was significantly increased from 3 days after MI. The level of plasma renin activity in the MI hamsters was significantly increased at the early phase of MI (1 - 3 days), while no significant changes in plasma ACE activity were observed. The ACE activity in the infarcted left ventricle was significantly increased starting from 3 days after MI and this increase was sustained up to 28 days. The chymase activity in the infarcted left ventricle was significantly increased starting from 1 day after MI and this increase was sustained up to 56 days. The number of chymase-positive mast cells in the infarcted left ventricle was significantly higher than in the sham group 3 and 7 days after operation. Treatment with an angiotensin (Ang) II type 1 receptor antagonist (candesartan cilexetil, 10 mg/kg per day) starting 3 days before the induction of MI significantly reduced the mortality rate during 14 days of observation following MI, whereas treatment with an ACE inhibitor (lisinopril, 20 mg/kg per day) did not. A significant improvement in hemodynamics (maximal negative and positive rates of pressure development, left ventricular systolic pressure and end-diastolic pressure, mean arterial blood pressure) was observed by the treatment with candesartan cilexetil, but not with lisinopril, 3 and 14 days after MI. These results suggested that Ang II produced by chymase may participate in the pathophysiologic state after MI in hamsters.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 86 (2), 203-214, 2001
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282679262315008
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- NII論文ID
- 10007122261
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- NII書誌ID
- AA00691188
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- COI
- 1:CAS:528:DC%2BD3MXkslehsrw%3D
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- ISSN
- 13473506
- 00215198
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- NDL書誌ID
- 5817469
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- PubMed
- 11459123
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可