Diltiazem Ameliorates Contractile Dysfunction Without Shortening of Action Potential Duration in Ischemic Heart of Anesthetized Dogs.

• Hamada Kaori

  Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, University of Tokyo

• Yamazaki Jun

  Department of Pharmacology, Fukuoka Dental College

• Nagao Taku

  Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, University of Tokyo

抄録

The purpose of the following experiment was to determine whether amelioration of myocardial contractile dysfunction by diltiazem is mediated by shortening of monophasic action potential duration (MAPD) during myocardial ischemia in anesthetized dogs. Diltiazem improved regional contraction during reperfusion after 10-min occlusion. The shortening of MAPD and increase in [K⁺]_e were blunted by treatment with diltiazem. These results suggest that shortening of action potential duration during myocardial ischemia is unlikely to be a reason for the amelioration of contractile dysfunction.

収録刊行物

• Jpn.J.Pharmacol.

  Jpn.J.Pharmacol. 86 (2), 251-253, 2001

  公益社団法人 日本薬理学会

キーワード

• Diltiazem
• Ischemic heart
• Action potential duration

詳細情報

• CRID: 1390282679262353792
• NII論文ID: 10007122436
• NII書誌ID: AA00691188
• DOI: 10.1254/jjp.86.251
• COI: 1:CAS:528:DC%2BD3MXkslehsrc%3D
• ISSN: 13473506
• ISSN: 00215198
• NDL書誌ID: 5817588
• PubMed: 11459130
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I5817588
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819303750?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819303750?httpAccept=text/plain
• Web Site: https://search.jamas.or.jp/link/ui/2001269875
• 本文言語コード: en
• データソース種別:
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  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
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