Blunt Cell Growth Potential in Carcinogen Resistant Inbred DRH Rats.

• YAMASHIRO Kenzo

  Department of 3rd Internal Medicine, School of Medicine, University of Occupational and Environmental Health

• YAN Ying

  Department of Biochemistry, School of Medicine, University of Occupational and Environmental Health

• FUKAMACHI Yukiyo

  Department of 2nd Surgery, School of Medicine, Tokyo Women's Medical University

• GOTOH Sadao

  Department of Biochemistry, School of Medicine, University of Occupational and Environmental Health

• HIGASHI Ken

  Department of Biochemistry, School of Medicine, University of Occupational and Environmental Health

• OHTSUKI Makoto

  Department of 3rd Internal Medicine, School of Medicine, University of Occupational and Environmental Health

• HAMADA Yuji

  Seac Yoshitomi, Ltd.

• HIGASHI Taneaki

  College of Nutrition, Koshien University

抄録

A carcinogen-resistant inbred strain DRH/Sea has been developed from the Crj:Donryu strain. The rats had a very low incidence of liver tumors when they were fed diets containing a hepatocarcinogen such as 3'-methyl-4-dimethylamino-azobenzene (3'-Me-DAB). Despite using 3'-Me-DAB during the stage of selection, the DRH/Sea rats developed normally, reproduced and did not have any spontaneous tumor in the lung, liver or uterus at over 1 year of age. Although their growth curves were similar to the Crj:Donryu rats, the progression of polyploidization in the liver was significantly delayed when compared with Crj:Donryu rats. Mitogenic changes that occurred in the liver caused by either 3'-Me-DAB or lead nitrate were less significant in the DRH rats than in Crj:Donryu rats. Furthermore, the growth rate of cultured fibroblasts derived from the DRH rats was slower than that of Crj:Donryu rats. These results, together with our previous results, suggest that slow growth potential is present under certain conditions in DRH rats. These findings may explain partly the meaning of the different susceptibility to hepatocarcinogens.<br>

収録刊行物

• Experimental Animals

  Experimental Animals 49 (1), 47-50, 2000

  公益社団法人 日本実験動物学会

キーワード

• carcinogen-resistant rat
• DRH/Sea
• growth potential
• ploidy

詳細情報

• CRID: 1390001205040980992
• NII論文ID: 10007343269
• NII書誌ID: AA11032321
• DOI: 10.1538/expanim.49.47
• ISSN: 18817122
• ISSN: 00075124
• ISSN: 13411357
• NDL書誌ID: 4960276
• PubMed: 10803362
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4960276
• Web Site: http://www.jstage.jst.go.jp/article/expanim/49/1/49_1_47/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可