Protective Effect of Passive Immunization against NTF-α in Mice Infected with Sendai Virus

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  • IWAI Hiroshi
    Department of Veterinary Microbiology, Faculty of Veterinary Medicine, Rakuno Gakuen University
  • MORIOKA Ayako
    Department of Veterinary Microbiology, Faculty of Veterinary Medicine, Rakuno Gakuen University
  • SHOYA Yuko
    Department of Veterinary Microbiology, Faculty of Veterinary Medicine, Rakuno Gakuen University
  • OBATA Yuji
    Department of Veterinary Microbiology, Faculty of Veterinary Medicine, Rakuno Gakuen University
  • GOTO Masamitsu
    Department of Veterinary Microbiology, Faculty of Veterinary Medicine, Rakuno Gakuen University
  • KIRISAWA Rikio
    Department of Veterinary Microbiology, Faculty of Veterinary Medicine, Rakuno Gakuen University
  • OKADA Hiroyuki
    Department of Veterinary Pathology, Faculty of Veterinary Medicine, Rakuno Gakuen University
  • YOSHINO Tomo-o
    Department of Veterinary Pathology, Faculty of Veterinary Medicine, Rakuno Gakuen University

書誌事項

タイトル別名
  • Protective Effect of Passive Immunization against TNF-.ALPHA. in Mice Infected with Sendai Virus.
  • Protective Effect of Passive Immunizati

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抄録

TNF-α has been reported to be induced in mice infected with Sendai virus. We evaluated the role of TNF-α in the virus infection. TNF-α was induced locally in proportion to virus titers in the lung. The activity was correlated with suppression of body weight gain. Passive immunization against TNF-α improved body weight gain and ameliorated pneumonic lesions in infected mice, and prevented them from lethal infection, but lung virus titers were not affected by passive immunization. These results indicate that Sendai virus-induced emaciation, pneumonic lesions and death were mediated by TNF-α.<br>

収録刊行物

  • Experimental Animals

    Experimental Animals 47 (1), 49-54, 1998

    公益社団法人 日本実験動物学会

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