Effects of olopatadine hydrochloride on the cutaneous vascular hyper-permeability and scratching behavior induced by poly-L-arginine in rat

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  • Hayashi Ken-ichi
    Drug Development Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Ltd.
  • Kaise Toshihiko
    Drug Development Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Ltd.
  • Ohmori Kenji
    Drug Development Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Ltd.
  • Ishii Akio
    Drug Development Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Ltd.
  • Karasawa Akira
    Drug Development Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Ltd.

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タイトル別名
  • Effects of Olopatadine Hydrochloride on the Cutaneous Vascular Hyperpermeability and the Scratching Behavior Induced by Poly-L-Arginine in Rats.

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抄録

Intradermal injections of poly-<sc>L</sc>-arginine induce cutaneous vascular hyperpermeability and scratching behavior in rats. Recently, we elucidated that the plasma extravasation involved both histamine and substance P, while the scratching behavior involved substance P, but not histamine. This study examined the effects of olopatadine hydrochloride (olopatadine), an antiallergic drug with histamine H1-antagonistic action, on the poly-<sc>L</sc>-arginine-induced responses. Olopatadine (1 mg/kg, p.o.) significantly inhibited both the plasma extravasation and the scratching behavior, suggesting that its inhibitory effects are mediated by the suppression of neuropeptidergic action as well as histaminic action. Olopatadine seems to be a novel-type drug for the treatment of dermatitis.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 87 (2), 167-170, 2001

    公益社団法人 日本薬理学会

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