A Possible Mechanism of Increase in Serum Alkaline Phosphatase Activity in Rats Given Granulocyte Colony-Stimulating Factor.

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  • KATO Yuzuru
    Toxicological Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
  • YAMAMOTO Mitsuo
    Toxicological Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
  • IKEGAMI Jiro
    Toxicological Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
  • OKUMURA Shuzo
    Toxicological Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
  • HARA Takuji
    Toxicological Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
  • SHUTO Katsuichi
    Toxicological Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.

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タイトル別名
  • Possible Mechanism of Increase in Serum

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抄録

Recombinant human granulocyte colony-stimulating factor (G-CSF) at a dose of 1 to 300 μg/kg/day was administered intravenously to rats daily for 13 weeks. Serum alkaline phosphatase (ALP) activity increased dose-dependently with leukocytosis. Most of the increased leukocytes were segmented neutrophils, and neutrophil alkaline phosphatase (NAP) scores were elevated markedly. Serum ALP activity correlated very well with the segmented neutrophil counts, and the coefficient of correlation was more than 0.97 in both sexes. Pathological examinations revealed splenomegaly and a marked increase in neutrophils in the red pulp of the spleen. In the spleen, phagocytosis of neutrophils by macrophages was observed. These data indicate that the increased ALP was of neutrophil origin. Serum ALP activity may be increased by the direct release of ALP from the high number of neutrophils into the blood, or by the leakage of ALP into the blood mainly from the spleen where many neutrophils are pooled and destroyed by the macrophage system. <br>

収録刊行物

  • Experimental Animals

    Experimental Animals 45 (1), 23-32, 1996

    公益社団法人 日本実験動物学会

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