Immunohistochemical Study on the Deposition of Apolipoprotein E in Cerebral and Islet Amyloidoses in Cynomolgus Monkeys (Macaca fascicularis).
-
- NAKAMURA Shin'ichiro
- Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo
-
- KIATIPATTANASAKUL Wijit
- Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo
-
- NAKAYAMA Hiroyuki
- Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo
-
- ONO Fumiko
- Tsukuba Primate Center for Medical Science, National Institutes of Health
-
- SAKAKIBARA Ippei
- Tsukuba Primate Center for Medical Science, National Institutes of Health
-
- YOSHIKAWA Yasuhiro
- Tsukuba Primate Center for Medical Science, National Institutes of Health
-
- GOTO Naoaki
- Tokyo Pathology Center, Shin-Nippon Biomedical Laboratories, Ltd.
-
- DOI Kunio
- Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo
書誌事項
- タイトル別名
-
- Immunohistochemical Study on the Deposi
この論文をさがす
抄録
To investigate the role of apolipoprotein E (apo E) in amyloidoses of cynomolgus monkeys, the localization of apo E in cerebral amyloid, including senile plaques and cerebrovascular amyloid, and in islet amyloid was examined immunohistochemically. Mature types of senile plaques with amyloid deposits and cerebrovascular amyloid showed intense immunoreactivity to both antisera to apo E and amyloid β protein (Aβ). In contrast, diffuse plaques without obvious Congophilic amyloid showed weak immunoreactivity to antiserum to apo E, but intense reactivity to antiserum to Aβ. In addition, the number of these apo E-positive diffuse plaques was small compared with that of Aβ-positive plaques. On the other hand, diabetic islet amyloid that was negative with Aβ, reacted intensely with antiserum to apo E. These findings suggest that apo E plays an important role in amyloid fibril formation in several types of amyloidoses.<br>
収録刊行物
-
- Experimental Animals
-
Experimental Animals 45 (2), 199-203, 1996
公益社団法人 日本実験動物学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390001205041374720
-
- NII論文ID
- 10007528703
-
- NII書誌ID
- AA11032321
-
- ISSN
- 18817122
- 00075124
- 13411357
-
- NDL書誌ID
- 3956572
-
- PubMed
- 8726148
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可