Changes in Lymphokine-activated Killer Activity in Peripheral Blood Lymphocytes from Canine Transmissible Venereal Sarcoma Models.

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  • MIZUNO Shinya
    Department of Veterinary Surgery, Faculty of Veterinary Medicine, Hokkaido University The Institute of Experimental Animal Sciences, Osaka University Medical School
  • FUJINAGA Toru
    Department of Veterinary Surgery, Faculty of Veterinary Medicine, Hokkaido University
  • KUROSAWA Tsutomu
    The Institute of Experimental Animal Sciences, Osaka University Medical School

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タイトル別名
  • Changes in Lymphokine-activated Killer

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Time course changes in anti-tumor activity induced in peripheral blood lymphocytes (PBL) with recombinant human interleukin-2 (rhIL-2) and phytohemagglutinin-P (PHA) were studied in dogs implanted with canine transmissible venereal sarcoma (CTVS) as a tumor-bearing model. The rhIL-2-dependent and PHA-dependent cultures allowed selective proliferation of lymphocytes expressing Thy-1 antigens. The lymphocytes acquired a prolonged anti-tumor activity against the CTVS cells, starting from 2 weeks after the culture, indicating generation of lymphokine-activated killer (LAK) cells. The LAK cells showed serial growth in rhIL-2-containing culture medium for at least a further 2 weeks without loss of the anti-tumor activity.<br>

収録刊行物

  • Experimental Animals

    Experimental Animals 45 (3), 289-292, 1996

    公益社団法人 日本実験動物学会

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