Studies on the Metabolic Fate of Lamivudine (III): Absorption, Metabolism and Excretion of Lamivudine in Dogs.
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- TAKUBO Takatoshi
- ADME Section, Pre-clinical Research Department, Tsukuba Research Laboratories, Nippon Glaxo Ltd.
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- MORIYA Takahito
- ADME Section, Pre-clinical Research Department, Tsukuba Research Laboratories, Nippon Glaxo Ltd.
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- MINAMIDE Yoshiyuki
- ADME Section, Pre-clinical Research Department, Tsukuba Research Laboratories, Nippon Glaxo Ltd.
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- HIRAYAMA Seiji
- ADME Section, Pre-clinical Research Department, Tsukuba Research Laboratories, Nippon Glaxo Ltd.
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- KATO Toshihiro
- ADME Section, Pre-clinical Research Department, Tsukuba Research Laboratories, Nippon Glaxo Ltd.
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- NAKAMURA Ryoko
- ADME Section, Pre-clinical Research Department, Tsukuba Research Laboratories, Nippon Glaxo Ltd.
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- KINAMI Junji
- ADME Section, Pre-clinical Research Department, Tsukuba Research Laboratories, Nippon Glaxo Ltd.
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The absorption, metabolism and excretion of nucleoside analogue, lamivudine, were investigated after a single oral administration of 3H-lamivudine to male and female dogs at a dose of 2 mg/kg.<BR> 1. The total radioactivity in plasma reached the maximum at 0.9 hour after oral administration to male dogs and declined rapidly with a half-life of 2.9 hours. The concentrations of lamivudine in plasma reached the maximum at 0.8 hour after oral administration and declined with a half-life of 1.4 hours. Profiles of the plasma levels of total radioactivity or lamivudine in female dogs were similar to those in male dogs.<BR> 2. The ratio of plasma protein binding of radioactivity was below 17% and the ratio of distribution to erythrocytes of radioactivity was 35-38%, after oral administration to male dogs.<BR> 3. The excreted radioactivity in urine and feces was 85.3% and 9.5% of the dose in male dogs, respectively, 93.2% and 5.8% in female dogs within 168 hours after oral administration.<BR> 4. Lamivudine and two major metabolites, trans-sulphoxide of lamivudine and cytosine, were observed by the radio-HPLC analysis of urine collected from male and female dogs after oral administration.
収録刊行物
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- 薬物動態
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薬物動態 12 (2), 102-107, 1997
日本薬物動態学会
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詳細情報 詳細情報について
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- CRID
- 1390282679644611200
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- NII論文ID
- 10007530761
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- NII書誌ID
- AN10144117
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- ISSN
- 09161139
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可