書誌事項
- タイトル別名
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- Effects of the combination of new quinolones and a nonsteroidal anti-inflammatory drug, fenbufen, on the EEG of rabbits.
- ウサギ ノウハ ニ オヨボス ニューキノロン コウキンヤク ト ヒ ステロイド
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A combination of fenbufen, a non-steroidal anti-inflammatory drug and the new quinolone produces a central stimulating action. To confirm the action, we used 6 kinds of new quinolones: enoxacin, norfloxacin, ofloxacin, ciprofloxacin, lomefloxacin and tosufloxacin in this experiment. The convulsive effects of these drugs were tested on the EEG recorded from the neocortex and subcortical regions of the rabbits. Animals treated with fenbufen (50 ?? 200 mg/kg, p.o.) tended to have a high amplitude slow wave in their EEG. Rabbits treated with the new quinolones at the dose of 100 mg/kg, p.o., with the exception of tosufloxacin, also tended to show a high amplitude slow wave in their EEG. Each new quinolone given 30 min after fenbufen (50 mg/kg, p.o.) elicited characteristic spikes on the EEG. Then, high-frequency-spikes and epileptiform seizure waves appeared for a long experimental period with this combination. The combination of fenbufen and tosufloxacin (100 ?? 400 mg/kg, p.o.) caused no changes in EEG and behavior. The spike and epileptiform wave could be suppressed only temporarily with diazepam (1 ?? 4mg/kg, i.v.). These results suggest that combined use of fenbufen and one of the new quinolones, except for tosufloxacin, produces the seizure. Not only GABA but also several other mechanisms in the central nervous system may be involved in the convulsion.
収録刊行物
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- 日本薬理学雑誌
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日本薬理学雑誌 99 (1), 45-54, 1992
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282679249346944
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- NII論文ID
- 10007601337
- 130000758829
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- NII書誌ID
- AN00198335
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- COI
- 1:CAS:528:DyaK38XpvFaisg%3D%3D
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- ISSN
- 13478397
- 00155691
- http://id.crossref.org/issn/00155691
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- NDL書誌ID
- 3763750
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- PubMed
- 1313778
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可