GCQによる涙液中のバルプロ酸の定量　―涙液中の中枢系薬物濃度の意義―

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タイトル別名
  • DETERMINATION OF VALPROIC ACID IN TEAR BY GCQ -ASSESSEMENT OF THE CONCENTRATIONS OF DRUGS ACTING ON THE CENTRAL NERVOUS SYSTEM IN TEAR-

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The concentrations of sodium valproate (VPA) in tear and plasma by a quadrapole ion trap type GC/MS (GCQ) in a negative ion/chemical ionization/electroncapture mode. VPA was converted into the pentafluorobenzyl ester and was quantified by monitoring the ion of m/z 143. The VPA concentrations [C]Ts in the tear obtained from patients by non-invasive Schirmer method correlated very well with those of the unbound form in the plasma, indicating that the [C]TS will be used as a convenient index for monitoring the unbound VPA level in the patients.

収録刊行物

  • 薬物動態

    薬物動態 13 (supplement), 120-121, 1998

    日本薬物動態学会

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