耳下腺好酸性腺腫の１例

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  • A case of oxiphilic adenoma of the parotid gland.

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Background: Oncocytic tumors of the salivary gland are rare and few cytological reports are available. We describe characteristic cytological, histological, and electron microscopic features in a case of oxyphilic adenoma arising in the right parotid gland.<BR>Case: A 70-year-old woman reported a gradually growing mass in the right parotid region. Imprint cytology preparation contained tumor cells arranged in single and cohesive clusters of different sizes. Tumor cells had ample eosinophilic granular cytoplasm. Nuclei were round and eccentric in some tumor cells and occasionally had prominent nucleoli. Apparent nuclear atypia, overlapping nuclei, and mitosis were not be identified. Histologically, the tumor showed a proliferation of oncocytic cells, mainly in nests partly with glandular formation. Tumor invasion of the capsule or surrounding tissue was not seen. Electron microscopic examination also confirmed tumor cells had numerous mitochondria occupying the entire cytoplasm. Based on these findings, we diagnosed the tumor as an oxyphilic adenoma.<BR>Conclusion: The cytological features detailed above are highly suggestive of oncocytic tumors. Even though no evident nuclear atypia or brisk mitosis was seen in cytological specimens, further histological examination is required to confirm differentiation between oxyphilic adenoma and carcinoma.

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