聴覚の可塑性の臨床とその基礎　　コルチ器レベルにおける情報処理　　その可塑性

• 菅澤 正

  東京大学医学部耳鼻咽喉科学教室

書誌事項

タイトル別名

• Sound Processing in Organ of Corti and the Issue of Plasticity.
• ―その可塑性―

抄録

“Active cochlea”, a new idea for sound processing in organ of Corti, is explained. Neosynaptogenesis after overstimulation of sound suggests that the mature organ of Corti is not a rigid structure but may have plasticity. ACh and ATP may regulate sensitivity and input-output functions of the organ of Corti by inducing an intracellular Ca²⁺increase in the hair cell as a transmitter or co-transmitter of an olivo-cochlea bundle or as humoral factors. These bio-modulators also regulate cochlea function via active processing of supporting cells. Clinical applications of the protective effects of contraototoxicity in the neurotrophin family are discussed. Early stage insertion of a cochlea implant after hair cell loss is recommended to maintain spinal ganglion cells.

収録刊行物

• 音声言語医学

  音声言語医学 39 (3), 315-322, 1998

  日本音声言語医学会

キーワード

• 可塑性
• コルチ器
• ラセン神経節

詳細情報

• CRID: 1390282679874676352
• NII論文ID: 10007699893
• NII書誌ID: AN00034826
• DOI: 10.5112/jjlp.39.315
• ISSN: 18843646
• ISSN: 00302813
• Web Site: https://search.jamas.or.jp/link/ui/1999008310
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可