タンパク質の吸着がポリスルホン透析膜の有効荷電密度およびイオンの透過性に与える影響

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  • Effects of Protein Adsorption on Effective Charge Density and Ion Permeability of Polysulfone Dialysis Membrane.

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To clarify ion transport, it is important to evaluate changes in effective charge density and internal structure of the membrane after protein adsorption, because protein adsorption on the membrane may change both their charge and internal structure. Dialysis experiments at 310K were made with cocurrently-operated dialyzers (700 hollow fibers of 25cm long) composed of polysulfone membranes (PS-600, PS-620) to determine the permeability for hydrogenphosphate ion, CuSO4, NaCl and urea before and after cytochrome C and α-lactalbumin adsorption by the Wilson plot. Urea permeabilities of the membranes decreased after cytochrome C and α-lactalbumin adsorption, indicating the change in the internal structure of the membranes. Ion permeabilities of the membranes adsorbing cytochrome C was larger than that calculated from the change in the internal structure of the membranes that cause a decrease of the effective charge densities of the membranes and that adsorbing α-lactalbumin was close to that calculated from the change in internal structure of the membranes. In conclusion, ion permeability changes after protein adsorption because of altered effective charge density and internal structure of the polysulfone dialysis membranes, and the protein adsorption is an important factor to evaluate the performance of dialysis membrane for medical application.

収録刊行物

  • 人工臓器

    人工臓器 24 (3), 707-712, 1995

    一般社団法人 日本人工臓器学会

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