書誌事項
- タイトル別名
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- Concentrations of cisplatin in serum and in effusion after administration of cisplatin-releasing bioresorbable micropheres for patients with malignant pleural effusions.
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As a local chemotherapy for malignant diseases, cisplatinreleasing bioresorbable microspheres (CDDP-MS) were prepared using a polymer consisting of glycolic acid-L-lactic acid copolymer. An average diameter of CDDP-MS was about 1OO u m. In vitro, all the CDDP was released constantly during the 3 weeks from CDDP-MS. We administered CDDP-MS to the patients with malignant pleural effusions and assayed CDDP in serums and in effusions. After CDDP-MS administration, CDDP was detectable in the serum for two weeks and in the effusion until the time of extubation. CDDP concentrations in serum were always lower than those after the treatment with CDDP solution. Low CDDP concentration in serum contributed to the reduction of the systemic side effects. The total amount of drained CDDP was less than 1% of the administered dose. The cytology of the effusion was changed to negative. CDDP-MS administration required no hydration and the extubation was done on 5.0±1.52 days that was shorter than those treated with CDDP solution. In the control of malignant pleural effusions, CDDP-MS are superior to a CDDP solution and contributes to the improvement of thes patient's quality of life.
収録刊行物
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- 人工臓器
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人工臓器 26 (2), 529-533, 1997
一般社団法人 日本人工臓器学会
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詳細情報 詳細情報について
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- CRID
- 1390282679932960000
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- NII論文ID
- 10007718855
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- NII書誌ID
- AN00120167
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- ISSN
- 18836097
- 03000818
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
