ハタケシメジの投与が高血圧自然発症ラットの血圧に及ぼす影響

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タイトル別名
  • Effects of Hatakeshimeji (Lyophyllum decastes Sing.) Diet on Blood Pressure in Spontaneously Hypertensive Rats.
  • ハタケシメジ ノ トウヨ ガ コウケツアツ シゼン ハッショウ ラット ノ ケツアツ ニ オヨボス エイキョウ

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抄録

The effect of Hatakeshimeji (Lyophyllum decastes Sing.) diet on blood pressure in spontaneously hypertensive rats (SHR) was studied. The animals were fed experimental diets for 21 days and their cystolic blood pressures were measured by tail cuff method. The rats fed the diets containing powdered Hatakeshimeji fruit body at the levels of 10% (H 10-group) and 20% (H 20-group) showed a significantly lower blood pressure compared to the control group (C-group, Hatakeshimeji free). At the last day of the feeding term, the blood pressures of the C-group, the H 10-group, and the H 20-group were 227±9, 207±9, and 188±5mmHg, respectively. The hot-water extractable fraction of Hatakeshimeji lyophilized powder (HWE-A) was prepared through extraction in boiling water, followed by extraction with 75% acetone. The HWE-A showed 20 and 18% lower blood pressures 4.5 hours after the intragastric administration and 1.5 hours after the intraperitoneal injection, respectively.

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